内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>92% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Human IL-13, Tag Free (Catalog # IL3-H4217) at 10 μg/mL (100 μL/well) can bind Anti-IL13 MAb, Human IgG4 with a linear range of 0.5-8 ng/mL.

产品背景:
Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

产品描述:
This protein carries no "tag". The protein has a calculated MW of 13.4 kDa. The protein migrates as 20-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.