HSD17B8,羟类固醇脱氢酶17β抗体

产品编号HZ-11407R
英文名称HSD17B8
中文名称羟类固醇脱氢酶17β抗体（17β-HSD8）
别 名17 beta HSD 8; 17 beta hydroxysteroid dehydrogenase 8; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-oxoacyl-[acyl-carrier-protein] reductase; Beta ketoacyl [acyl carrier protein] reductase like; D6S2245E; DHB8_HUMAN; dJ1033B10.9; Estradiol 17 beta dehydrogenase 8; Estradiol 17-beta-dehydrogenase 8; Estrogen 17 oxidoreductase; FABG; FABGL; H2 KE6; HKE6; HSD17B8; Hydroxysteroid (17 beta) dehydrogenase 8; 17beta hydroxysteroid dehydrogenase type 8; Ke-6; KE6; Protein Ke6; Really interesting new gene 2 protein; RING2; SDR30C1; Short chain dehydrogenase/reductase family 30C member 1; Testosterone 17 beta dehydrogenase 8; Testosterone 17-beta-dehydrogenase 8.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit,
HSD17B8,羟类固醇脱氢酶17β抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human HSD17B8 (174-220aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
HSD17B8,羟类固醇脱氢酶17β抗体PubMedPubMed
产品介绍background:
17beta-HSD8 belongs to the 17beta-HSD family of proteins that regulate the availability of steroids within a tissue. 17beta-HSD8 converts active steroids to their inactive form through its oxidative activity. It is a key player in the inactivation of Estradiol and Testosterone. 17beta-HSD8 is predominantly expressed in placenta, endometrium and prostate but can also be found in liver, and pancreas, with lowest levels found in testis, ovary and kidney. It has been proposed that a reduction in the levels of 17beta-HSD8 may lead to abnormal elevations in the local level of sex steroids, which can lead to recessive renal cystic disease. It has also been suggested that low levels of 17beta-HSD proteins may result in an underdeveloped urogenital system.

Function:
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.

Subunit:
Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.

Subcellular Location:
Mitochondrion matrix.

Tissue Specificity:
Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.

Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.

HSD17B8,羟类固醇脱氢酶17β抗体Database links:
UniProtKB/Swiss-Prot: Q92506.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.