Tilorone | 替洛隆 | MedChemExpress (MCE)
产品名称: Tilorone | 替洛隆 | MedChemExpress (MCE)
英文名称: Tilorone
产品编号: HY-B1080A
产品价格: 240; 480; 760; 1200
产品产地: 美国
品牌商标: MedChemExpress (MCE)
更新时间: 2024-04-30T13:38:44
使用范围: null
规格 | 价格 |
10 mg; 25 mg; 50 mg |
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Tilorone
CAS No. : 27591-97-5
MCE 国际站:Tilorone
产品活性:Tilorone 是一种口服有效的抗病毒剂和干扰素诱导剂,还具有潜在抗肿瘤、免疫调节和代谢调节的作用。Tilorone 能够诱导干扰素反应异常延迟,并主要刺激淋巴组织产生干扰素。由此,Tilorone 产生抗病毒作用,可作为化疗剂用于。Tilorone 能够通过增强 Akt2/AS160 信号传导和葡萄糖转运蛋白水平来增加体内和骨骼肌细胞的葡萄糖摄取,有潜力抑制 2 型糖尿病。
研究领域:Anti-infection | PI3K/Akt/mTOR
作用靶点:Influenza Virus | Akt
In Vitro: Tilorone (0.8-500 μg/mL; 2 d) induces insignificant interferon production in peritoneal macrophages and lymphocytes.
Tilorone has 52% of human plasma proteins Binding rate, excellent plasma stability, mouse liver microsomal half-life of 48 minutes.
Tilorone (20, 35 nM; 40 h) increases bone morphology in myoblasts The expression of BMP and Smad4.
Tilorone (20, 35 nM; 40 h) can also increase the expression of GLUT and glucose uptake in C2C12 cells .
In Vivo: Tilorone (50-250 mg/kg; po; single dose) can induce a delayed but not prolonged interferon response; and affects circulating interferon levels in a dose-dependent manner.
The maximum tolerated single dose of Tilorone in mice is 100 mg/kg; pharmacokinetic results of Tilorone (2, 10 mg/kg; ip) in mice indicate that Tilorone has a high absorption rate and is The half-life in mice is 18 hours, but exposure in male mice is higher.
Tilorone (25-50 mg/kg; ip; once daily for 8 days ) protects 90% of Ebola virus-infected mice from lethal challenge.
Tilorone (25 mg/kg; iv; single dose) enhances immunity in small Uptake of the radiolabeled glucose analog 18F-fluoro-2-deoxyglucose in rats.
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