NAB2,EGR1结合蛋白2抗体

产品编号HZ-11299R
英文名称NAB2
中文名称EGR1结合蛋白2抗体
别 名EGR 1 binding protein 2; EGR-1-binding protein 2; EGR1 binding protein 2; MADER; Melanoma associated delayed early response protein; Melanoma-associated delayed early response protein; MGC75085; Nab 2; nab2; NAB2_HUMAN; NGFI A binding protein 2 (EGR1 binding protein 2); NGFI A binding protein 2; NGFI-A-binding protein 2; Protein MADER.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 细胞凋亡 转录调节因子 细胞分化 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
NAB2,EGR1结合蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MCM5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NAB2,EGR1结合蛋白2抗体PubMedPubMed
产品介绍background:
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2 are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas, and liposarcomas.

Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.

Subunit:
Homomultimers may associate with EGR1 bound to DNA (By similarity).

Subcellular Location:
Nucleus. Isoform 2 is not localized to the nucleus.

Tissue Specificity:
Widely expressed at low levels. Highly expressed in melanoma cell lines.

Post-translational modifications:
Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.

NAB2,EGR1结合蛋白2抗体Similarity:
Belongs to the NAB family.

Gene ID:
4665

Database links:
Entrez Gene: 4665 Human
Entrez Gene: 17937 Mouse
Omim: 602381 Human
SwissProt: Q15742 Human
SwissProt: Q61127 Mouse
Unigene: 159223 Human
Unigene: 336898 Mouse
Unigene: 470656 Mouse

NAB2,EGR1结合蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.