RBBP8抗体-抗体-抗体-生物在线
RBBP8抗体

RBBP8抗体

商家询价

产品名称： RBBP8抗体

英文名称： RBBP8Antibody

产品编号： XY 12624-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
  • 联系人 : 徐经理
  • 地址 : 上海市闵行莘庄工业区春东路508号A1-2F
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 152****8802
  • 传真 : 021-37680378
  • 邮箱 : shxysw02@163.com
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 RBBP8抗体Applications

In-house applications ELISA, WB     Application not tested? Please see our Guarantee.
Species specificity Human, mouse, rat; other species not tested.
Images
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  • 12624-1-AP;mouse testis tissuemouse testis tissue were subjected to SDS PAGE followed by western blot with 12624-1-AP(RBBP8 antibody) at dilution of 1:300
Positive WB detected in Mouse testis tissue, A431 cells, Jurkat cells, Raji cells
Recommended dilution WB : 1:200-1:2000
 RBBP8抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen RBBP8 fusion protein ag3314 Full name Retinoblastoma binding protein 8
Calculated molecular
weight		 103 kDa Observed molecular 
weight		 120kd
GenBank accession 
number		 BC030590 Gene ID (NCBI) 5932
Gene symbol RBBP8 Synonyms RBBP8, CTIP, RBBP 8, DNA endonuclease RBBP8, RIM
Background RBBP8抗体

RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. It functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. It interacted with BRCA1 to form a complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Also it promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations RBBP8抗体

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