SIRT5,沉默调节蛋白5抗体

产品编号HZ-9456R
英文名称SIRT5
中文名称沉默调节蛋白5抗体
别 名NAD dependent deacetylase sirtuin 5; NAD-dependent deacetylase sirtuin 5; NAD-dependent deacetylase sirtuin-5; Silent mating type information regulation 2 S.cerevisiae homolog 5; Sir2 like 5; Sir2-like 5; SIR2-like protein 5; SIR2L5; Sirt5; SIRT5_HUMAN; Sirtuin type 5.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
SIRT5,沉默调节蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from hu SIRT5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SIRT5,沉默调节蛋白5抗体PubMedPubMed
产品介绍background:
Sirtuins (SIRT1-7) are human homologs of the yeast Sir2 (silent information regulator-2) protein and are divided into four main classes: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. In S. cerevisiae, Sir2 deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA (ribosomal RNA) and silent mating-type loci. The human SIRT proteins are NAD-dependent deacetylases that act as intracellular regulators and are thought to have ribosyltransferase activity. SIRT5 (NAD-dependent deacetylase sirtuin-5), also known as SIR2L5, is a 310 amino acid member of the class III sirtuins. Localized to mitochrondria and expressed throughout the body, SIRT5 is an NAD-dependent deacetylase that may link metabolic aging processes in humans. SIRT5 contains one deacetylase-sirtuin-type domain and can be deactivated by suramin, a drug that blocks the binding of various growth factors. Two isoforms of SIRT5 exist due to alternative splicing events.

Subcellular Location:
Mitochondrion matrix. Mitochondrion intermembrane space.

Tissue Specificity:
Widely expressed.

Database links:
Entrez Gene: 23408 Human
Entrez Gene: 68346 Mouse
Omim: 604483 Human
SwissProt: Q3ZBQ0 Cow
SwissProt: E2RDZ6 Dog
SwissProt: Q9NXA8 Human
SwissProt: Q8K2C6 Mouse
SwissProt: Q5R6G3 Orangutan
Unigene: 567431 Human
Unigene: 594133 Human
Unigene: 35325 Mouse

SIRT5,沉默调节蛋白5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.