NFE2L2ProteinE79Qmutant-蛋白质/抗原/多肽-试剂-生物在线
NFE2L2ProteinE79Qmutant

NFE2L2ProteinE79Qmutant

商家询价

产品名称： NFE2L2ProteinE79Qmutant

英文名称： NFE2L2ProteinE79Qmutant

产品编号： 10449

产品价格： 0

产品产地： 美国

品牌商标： NewEastBio

更新时间： null

使用范围： null

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NFE2L2 Protein E79Q mutant [10449]
[100ul]		  
Catalog Number:  10449
Product Name:  NFE2L2 Protein E79Q mutant
Synonyms:  Nuclear factor (erythroid-derived 2)-like 2, Nrf2
Source:   Human, recombinant full length, His6-tag
Expression Host:   E. coli
Molecular Weight:   26 kDa
Purity:   >99% by SDS-PAGE
Introduction:   NFE2L2 protein is encoded by NFE2L2 gene. It is a basic leucine zipper protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
Amino Acid Sequence   (1-170)
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFD
FSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQL
DEQTGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDAL
YFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIE
SPVFIATNQAQSPETSVA
Properties
Physical Appearance (form):   Dissolved in 20mM Tris-HCl, pH8.0, 150mM NaCl.
Physical Appearance (form):  White or clear
Concentration:  1 mg/mL
Storage:   -80°C
Preparation Instructions:  
Adding of 10 mM β-mercaptoethanol or 1 mM DTT into the solution to protect the protein is recommended and using of non-ionic detergents such as n-Dodecyl β-D-maltoside (DoDM) or polyethylene detergents (e.g. C12E10) also help to stabilize the protein. Avoid repeated freezing and thawing.

The purity of His-tagged NFE2L2 E79Q was determined by SDS-PAGE and Coomassie Brilliant Blue Staining.
References:  
1. Moi P et al., Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9926-30. 
2. Gold R et al., N. Engl. J. Med. 367 (12): 1098-107.