The Matrix Metalloproteinase (MMP) Family
Enzyme E.C. No. Pseudonyms Mol. Wt. Collagen Additional Substrates
(Latent/Active) Substrates
MMP-1 3.4.24.7 Collagenase-1, Fibroblast Collagenase, 55,000/45,000 I, II, III, VII, Aggrecan, Gelatin, MMP-2, MMP-9
Interstitial Collagenase, Tissue Collagenase VIII, X
MMP-2 3.4.24.24 72 kDa Gelatinase, 72 kDa Gelatinase/Type IV 72,000/66,000 I, II, III, IV, V, Aggrecan, Elastin, Fibronectin,
Collagenase, Gelatinase A, TBE-1 VII, X, XI Gelatin, Laminin, MMP-9, MMP-13
MMP-3 3.4.24.17 Procollagenase, PTR1 protein, SL-1, 57,000/45,000 II, III, IV, IX, Aggrecan, Elastin, Fibronectin,
Stromelysin-1, Transin-1 X, XI Gelatin, Laminin, MMP-7,
MMP-8, MMP-13
MMP-7 3.4.24.33 Matrilysin, Matrin, PUMP-1 Protease, Uterine 28,000/19,000 IV, X Aggrecan, Elastin, Fibronectin,
Metalloproteinase Gelatin, Laminin, MMP-1,
MMP-2, MMP-9
MMP-8 3.4.24.34 Collagenase–2, Neutrophil Collagenase, 75,000/58,000 I, II, III, V, VII, Aggrecan, Elastin, Fibronectin,
PMNL Collagenase VIII, X Gelatin, Laminin
MMP-9 3.4.24.25 92 kDa Gelatinase, 92 kDa Gelatinase/Type IV 92,000/86,000 IV, V, VII, X, Aggrecan, Elastin, Fibronectin,
Collagenase, Gelatinase B XIV Gelatin
MMP-10 3.4.24.22 SL-2, Stromelysin-2, Transin-2 57,000/44,000 III, IV, V Aggrecan, Elastin, Fibronectin,
Gelatin, Laminin, MMP-1, MMP-8
MMP-11 SL-3, Stromelysin-3, ST-3 51,000/44,000 Aggrecan, Fibronectin, Laminin
MMP-12 3.4.24.65 HME, Macrophage Metalloelastase 54,000/45,000 IV Elastin, Fibronectin, Gelatin,
MME and 22,000 Laminin
MMP-13 Collagenase-3 60,000/48,000 I, II, III, IV Aggrecan, Gelatin
MMP-18 Xenopus Collagenase-4, xCol4 70,000/53,000
MMP-19 RASI-1 54,000/45,000 IV Fibronectin, Aggrecan, COMP,
Laminin, Gelatin
MMP-20 Enamelysin 54,000/22,000 Aggrecan, Amelogenin, COMP
MMP-23 CA-MMP
MMP-26 Matrilysin-2, Endometase 28,000/19,000 IV Gelatin, Fibronectin
MMP-28 Epilysin
MT1-MMP MMP-14, Membrane-Type Metalloproteinase-14 66,000/56,000 I, II, III Aggrecan, Elastin, Fibronectin,
Gelatin, Laminin, MMP-2, MMP-13
MT2-MMP MMP-15, Membrane-Type Metalloproteinase-15 72,000/60,000 Fibronectin, Gelatin, Laminin, MMP-2
MT3-MMP MMP-16, Membrane-Type Metalloproteinase-16 64,000/52,000 MMP-2
MT4-MMP MMP-17, Membrane-Type Metalloproteinase-17 57,000/53,000 Fibrin, Gelatin
MT5-MMP MMP-24 –/62,000
MT6-MMP MMP-25, Leukolysin IV Gelatin, Fibronectin, Laminin-I