青链双抗
产品名称： 青链双抗
英文名称： Penicillin-Streptomycin Solution
产品编号： 03-031-1B
产品价格： 0
产品产地： 以色列
品牌商标： Biological industries（BI）
更新时间： null
使用范围： null
- 联系人 : 市场部
- 地址 : 上海市浦东新区祖冲之路1505弄80号1幢3楼
- 邮编 : 200120
- 所在区域 : 上海
- 电话 : 189****5545
- 传真 : 021-58777053
- 邮箱 : Never.huang@xpbiomed.com
Product Description：
Penicillin-Streptomycin is an Aminoglycoside-β Lactam antibiotic combination solution. It accords broad-spectrum bactericidal activity against both gram-positive and gram-negative bacteria. The Mode of Action (MOA) of Penicillin G interferes with the final stage of synthesis of the bacterial cell wall causing disruption of the osmotic pressure gradient with ensuing lysis and cell death, whereas the MOA of Streptomycin Sulfate modifies the permeability of the cell wall, interferes with prokaryote protein synthesis and cellular respiration by irreversibly binding to the 30S ribosome subunit to cause a misreading/miscoding of the mRNA.
In essence, this activity freezes the 30S initiation complex (i.e.30S-mRNA-tRNA) and interrupts any further progress in the initiation phase to chain-elongating riboome. Both antibiotics, Penicillin, a β-Lactam moiety when combined with Streptomycin, an Aminoglycoside moiety, synergistically enhance their range of activities and increase their effectiveness as opposed to when utilized on an individual basis.
The efficacy of a Penicillin-Streptomycin synergistic combination is accomplished when two individual drugs (i.e. both are bactericidal) interfere with different constituents in the bacterial cellular or metabolic pathways. The result is an effect greater than could be attributed to additiveaction. In theory, a drug affecting the permeability of the cell membrane (i.e. streptomycin), plus a drug affecting the cell wall (i.e. penicillin), when used in combination, may be more effective than either drug used alone. In this case, there is even evidence of synergism between thetwo-drugs.
| Instructions/Procedure |
| The product should be stored at –20ºC and allowed to thaw to room temperature prior to use. The contents should not be left in the light for |
| prolonged periods as it is light-sensitive. When stored in the dark under ideal conditions, the product is stable until the expiry date. |
1) Take a bottle out from proper storage conditions at –20ºC and read the label.
2) Thaw to room temperature.
3) Ensure that the cap of the bottle is tight.
4) Gently swirl the solution in the bottle.
5) Wipe the outside of the bottle with a disinfectant solution such as 70% ethanol.
6) Using aseptic/sterile technique under a laminar-flow culture hood, work according to established protocols.
7) Recommended Use: 1: 100
产品官网链接：https://www.bioind.com/worldwide/penicillin-streptomycin-solution/