Calcipressin 1/DSCR 1,唐氏综合征候选区域蛋白1样蛋白1抗体

产品编号HZ-11541R
英文名称Calcipressin 1/DSCR 1
中文名称钙调神经磷酸酶调节蛋白1抗体（唐氏综合征候选区域蛋白1样蛋白1）
别 名Adapt 78; Adapt78; Calcipressin 1; Calcipressin-1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; DSCR-1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1; RCAN1_HUMAN; RCN 1; RCN1; Regulator of calcineurin 1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
Calcipressin 1/DSCR 1,唐氏综合征候选区域蛋白1样蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Calcipressin 1 (101-200aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Calcipressin 1/DSCR 1,唐氏综合征候选区域蛋白1样蛋白1抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

Subunit:
Interacts with RAF1.

Tissue Specificity:
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Similarity:
Belongs to the RCAN family.

Database links:
Entrez Gene: 1827 Human
Entrez Gene: 54720 Mouse
Entrez Gene: 266766 Rat
Omim: 602917 Human
SwissProt: P53805 Human
SwissProt: Q9JHG6 Mouse
SwissProt: Q6IN33 Rat
Unigene: 282326 Human
Unigene: 265744 Mouse
Unigene: 12942 Rat

Calcipressin 1/DSCR 1,唐氏综合征候选区域蛋白1样蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-DSCR1 Polyclonal Antibody, Unconjugated(HZ-11541R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining