Anti-GCR Polyclonal Antibody

商品货号：	商品品牌：	规格	基本售价：	选择规格
K101529P-50ul	solarbio	50ul	960.00元
K101529P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-GCR Polyclonal Antibody
别名	GCCR;GCR;GCRST;GR;GRL
应用	WB
稀释比例	WB 1:3000.
交叉反应	Human
蛋白分子量	86kDa
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human GCR
性状	液体
Public Immunogen Range	A synthetic peptide of human GCR
Subcellular Locations	Cytoplasm Mitochondrion Nucleus Nucleus
Swiss Prot	P04150
克隆类型	Polyclonal Antibody
背景资料	Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5 UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.