Anti-Calcyon/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Calcyon/FITC Conjugated抗体

Anti-Calcyon/FITC Conjugated抗体

商家询价

产品名称： Anti-Calcyon/FITC Conjugated抗体

英文名称： Anti-Calcyon/FITC

产品编号： YB--11719R-FITC

产品价格： null

产品产地： 中国/美国

品牌商标： Ybscience

更新时间： 2023-08-17T10:29:50

使用范围： 科研使用

上海钰博生物科技有限公司
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 Anti-Calcyon/FITC Conjugated抗体

产品编号 YB-11719R-FITC
英文名称 Anti-Calcyon/FITC
中文名称 FITC标记的多巴胺D1受体相互作用蛋白抗体
别    名 CALCYON; Drd1ip; Caly; CALY_HUMAN; D1 dopamine receptor interacting protein; Drd1ip; Neuron specific vesicular protein calcyon; Neuron-specific vesicular protein calcyon; NSG3; RP11-122K13.5.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  细胞膜受体  跨膜蛋白  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Calcyon (3-65aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Calcyon is a single transmembrane protein that interacts with D1 dopamine receptors. Dopamine is a neurotransmitter that regulates synaptic transmission involved in learning and memory. D1 receptors, the most abundant dopamine receptor in the central nervous system, appear to modulate the activity of D2 dopamine receptors, mediate various behavioural responses, and regulate neuron growth and differentiation. Calcyon is present in neuronal cell bodies and processes of the cortex and hippocampus, and it is especially abundant in pyramidal neurons. Interaction of Calcyon with D1 receptors results in a release of intracellular calcium.

Function:
Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Subunit:
nteracts with CLTA. 

Subcellular Location:
Cytoplasmic vesicle membrane. Cell membrane.

Tissue Specificity:
Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the NSG family.

Database links:

Entrez Gene: 50632 Human

Entrez Gene: 68566 Mouse

Entrez Gene: 192349 Rat

Omim: 604647 Human

SwissProt: Q9NYX4 Human

SwissProt: Q9DCA7 Mouse

SwissProt: P58821 Rat

Unigene: 148680 Human

Unigene: 44241 Mouse

Unigene: 27756 Rat

 

 

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications