AP3B1抗体
Applications
| In-house applications |
ELISA, WB, IP Application not tested? Please see our Guarantee. |
| Published applications |
IF, WB |
Publications |
6 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human |
|
Images
Prev1Next
 mouse thymus tissue were subjected to SDS PAGE followed by western blot with 13384-1-AP(AP3B1 antibody) at dilution of 1:500 IP Result of anti-AP3B1 (IP:13384-1-AP, 3ug; Detection:13384-1-AP 1:500) with COLO 320 cells lysate 2500ug.
|
| Positive WB detected in |
Mouse thymus tissue, COLO 320 cells |
| Positive IP detected in |
COLO 320 cells |
| Recommended dilution |
WB : 1:500-1:5000
IP : 1:200-1:2000 |
AP3B1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
AP3B1 fusion protein ag4225 |
Full name |
Adaptor-related protein complex 3, beta 1 subunit |
Calculated molecular
weight |
1094aa,121 kDa |
Observed molecular
weight |
140 kDa |
GenBank accession
number |
BC038444 |
Gene ID (NCBI) |
8546 |
| Gene symbol |
AP3B1 |
Synonyms |
ADTB3, ADTB3A, AP 3 complex subunit beta 1, AP3B1, Beta 3A adaptin, HPS, HPS2, PE |
Background AP3B1抗体
|
AP3B1 is the 140-kDa β3A subunit of the adaptor-related protein complex-3 (AP-3), a ubiquitous heterotetrameric complex that is localized to the trans-Golgi network and endosomes and is involved in protein trafficking to lysosomes or specialized endosomal-lysosomal organelles (PMID: 9182526; 9545220). This complex is composed of two lager subunits (δ and β3A or β3B), a medium subunit (μ3A or μ3B), and a small subunit (σ3A or σ3B). The absence of the β3A subunit (AP3B1) results in the loss of stability of AP3 and leads to degradation of μ3A, to which β3A is directly bound, while the other subunits are variably affected (PMID: 16507770). AP3B1 contains three main domains: the N-terminal head domain, the hinge, and the C-terminal ear domain. It has been reported as a target of IP(7)-mediated pyrophosphorylation (PMID: 19934039). Defects in AP3B1 are the cause of Hermansky-Pudlak syndrome type 2 (HPS2) (PMID: 10024875; 16507770). AP3B1抗体
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