FITC标记的大脑和睾丸特异性免疫球蛋白超家族成员11抗体
产品名称： FITC标记的大脑和睾丸特异性免疫球蛋白超家族成员11抗体
英文名称： Anti-IGSF11/FITC
产品编号： HZ-9201R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-IGSF11/FITC Conjugated antibody
FITC标记的大脑和睾丸特异性免疫球蛋白超家族成员11抗体
| 产品编号 | bs-9201R-FITC |
| 英文名称 | Anti-IGSF11/FITC |
| 中文名称 | FITC标记的大脑和睾丸特异性免疫球蛋白超家族成员11抗体 |
| 别 名 | brain and testis specific immunoglobin superfamily protein; BTIGSF; CXADR like 1; CXADRL1; Igsf13; immunoglobulin superfamily member 11; Immunoglobulin superfamily member 11 precursor; MGC35227; V set and immunoglobulin domain containing 3; V set and immunoglobulin domain containing protein 3; VSIG3; IGS11_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞膜受体 细胞表面分子 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGSF11 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy. Function: Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth. Subcellular Location: Cell Membrane, Single-pass type I membrane protein. Tissue Specificity: bundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle. Post-translational modifications: N-glycosylated (By similarity). Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 152404 Human Entrez Gene: 207683 Mouse Entrez Gene: 303926 Rat Omim: 608351 Human SwissProt: Cow SwissProt: Q5DX21 Human SwissProt: P0C673 Mouse SwissProt: Q5U2P2 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IGSF11也被称为BTIGSF（脑和睾丸特异性免疫球蛋白超家族蛋白）或VSIG3（V-SET和免疫球蛋白域包含蛋白3），并且是431种氨基酸蛋白，其表达为三种异构体。IGFS11在睾丸和卵巢中高表达，并在脑、肾和骨骼肌中表达，定位于细胞膜作为单遍膜蛋白。IgSF11是一种具有V型和C2型结构域的免疫球蛋白，在分子识别中发挥作用。当IGFS11在反式位置时，它通过与其它分子的亲同性和异嗜性相互作用在细胞-细胞粘附中起着重要的作用。这些细胞-细胞相互作用也被认为是重要的神经细胞相互作用，如神经元-神经元或神经元-神经胶质相互作用，这对于中枢神经系统的发育和功能是很重要的。此外，IGFS11还可能参与Sertoli细胞和精母细胞之间的相互作用，精母细胞是精子发生过程中的重要联系。IGFS11基因在胃癌中普遍上调，IGFS11在多种类型的肿瘤中高表达，提示其可能作为免疫治疗的靶点。