FITC标记的胰岛素样生长因子结合蛋白样1抗体
产品名称： FITC标记的胰岛素样生长因子结合蛋白样1抗体
英文名称： Anti-IGFBPL1/FITC
产品编号： HZ-15569R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-IGFBPL1/FITC Conjugated antibody
FITC标记的胰岛素样生长因子结合蛋白样1抗体
| 英文名称 | Anti-IGFBPL1/FITC |
| 中文名称 | FITC标记的胰岛素样生长因子结合蛋白样1抗体 |
| 别 名 | bA113O24.1; IGFBP-related protein 10; IGFBP-RP4; IGFBPRP4; insulin-like growth factor binding protein related protein 4; insulin-like growth factor-binding protein-like 1; IBPL1_HUMAN; insulin-like growth factor-binding-related protein 4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGFBPL1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IGFBPL1 is a secreted IGF (Insulin-like growth factor) binding protein that is known to contain an Ig-like C2-type (immunoglobulin-like) domain, an IGFBP N-terminal domain and a Kazal-like domain. IGF-binding proteins characteristically act to extend the half-life of IGFs and may influence the growth promoting effects of the IGFs. The interaction of IGFBPs with IGFs can affect cell surface receptors, specifically, IGFBPs may enhance or decrease a cells insulin sensitivity. IGFBPL1 has been found to be down-regulated in multiple tumors and thus may be a likely tumor suppressor candidate. Highly expressed in both brain and testis, IGFBPL1 is found at lower levels in the prostate, bladder and lung. Function: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. Subcellular Location: Secreted. Tissue Specificity: Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 Kazal-like domain. Database links: Entrez Gene: 347252 Human Omim: 610413 Human SwissProt: Q8WX77 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IGFBPL1是分泌的胰岛素样生长因子（.ulin-like.factor，胰岛素样生长因子）结合蛋白，已知其包含Ig样C2型（免疫球蛋白样）结构域、IGFBP N端结构域和Kazal样结构域。胰岛素样生长因子结合蛋白具有延长胰岛素样生长因子半衰期的特性，并可能影响胰岛素样生长因子的生长促进作用。IGFBPs与IGFs的相互作用可影响细胞表面受体，特别是IGFBPs可增强或降低细胞胰岛素敏感性。IGFBPL1已被发现在多个肿瘤中下调，因此可能是一个可能的肿瘤抑制候选物。IGFBPL1在前列腺和膀胱、肺组织中均表达水平较低。