Recombinant Human Beta Klotho Protein, His Tag
产品名称： Recombinant Human Beta Klotho Protein, His Tag
英文名称： Recombinant Human Beta Klotho Protein, His Tag
产品编号： 94201ES25
产品价格： 0
产品产地： Yeasen
品牌商标： Yeasen
更新时间： 2023-08-17T13:40:59
使用范围： null
- 联系人 : 李自转
- 地址 : 上海市浦东新区天雄路166弄一号楼三层南单元
- 邮编 : 200030
- 所在区域 : 上海
- 电话 : 139****5640
- 传真 : 021-34615995-188
- 邮箱 : lizizhuan@yeasen.com
产品描述
Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Like Klotho, Klotho beta facilitates binding between FGF19 subfamily members and their receptors via formation of a ternary complex. The Klotho beta mediated interaction of human FGF19 with FGF Receptor 4 in the liver negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes, cholesterol 7-alpha hydroxylase and sterol 12-alpha hydroxylase
产品性质
Synonyms | betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; β-klotho; klotho β like; Klotho β |
Uniprot No. | Q86Z14 |
Source | HEK293 Cells-derived Human Beta Klotho Protein, Met30-Thr983 with His tag at the C-terminal |
Molecular Weight | Approximately 111.6 kDa. Due to glycosylation, the protein migrates to 115-130 kDa based on Tris-Bis PAGE result. |
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity | > 95% as determined by SDS-PAGE and HPLC |
Endotoxin | < 1.0 EU per 1μg of the protein by the LAL method. |
Formulation | TUNEology 波长可调检测卡盒-->
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