FITC标记的蛋白酪氨酸磷酸酶H1抗体
产品名称： FITC标记的蛋白酪氨酸磷酸酶H1抗体
英文名称： Anti-PTPH1/FITC
产品编号： HZ-9187R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PTPH1/FITC Conjugated antibody
FITC标记的蛋白酪氨酸磷酸酶H1抗体
| 产品编号 | bs-9187R-FITC |
| 英文名称 | Anti-PTPH1/FITC |
| 中文名称 | FITC标记的蛋白酪氨酸磷酸酶H1抗体 |
| 别 名 | cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase H1; protein tyrosine phosphatase non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3_HUMAN; PTP H1; PTP-H1; PTPH1; PTPN3; Tyrosine-protein phosphatase non-receptor type 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 激酶和磷酸酶 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 104kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTPH1/PTPN3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. PTP-H1 shares homology with the cytoskeletal-associated proteins band 4.1, ezrin, and talin and has been shown to contain a PDZ and band 4.1 domain. These domains are responsible for targeting proteins to the cytoskeleton-membrane interface, as well as mediating protein-protein interactions, recognizing C-terminal valine residues and binding to other PDZ domains. Overexpression of PTP-H1 may reverse transformation induced by oncogenic protein-tyrosine kinases, such as the members of the src family. Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Subcellular Location: Cell membrane. Cytoplasm. cytoskeleton. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 PDZ (DHR) domain. Contains 1 tyrosine-protein phosphatase domain. Database links: Entrez Gene: 5774 Human Entrez Gene: 545622 Mouse Omim: 176877 Human SwissProt: P26045 Human SwissProt: A2ALK8 Mouse Unigene: 436429 Human Unigene: 246552 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白质在酪氨酸残基上的磷酸化一直被认为是信号转导的重要调控成分。这是一个可逆的过程，涉及两种酶，酪氨酸残基上磷酸化的蛋白质，以及蛋白质酪氨酸磷酸酶迅速扩展的家族。这些后一种酶与蛋白丝氨酸和蛋白苏氨酸磷酸酶或酸性和碱性磷酸酶几乎没有相似之处。在大多数组织中，主要的PTP酶是钒酸盐和钼酸盐敏感蛋白。PTP－H1与细胞骨架相关蛋白带4.1、Ezrin和Talin有同源性，并已显示含有PDZ和带4.1结构域。这些域负责靶向蛋白质到细胞骨架膜界面，以及介导蛋白质-蛋白质相互作用，识别C-末端缬氨酸残基和结合到其他PDZ结构域。PTP－H1的过度表达可能逆转致癌蛋白酪氨酸激酶诱导的转化，如Src家族成员。