PDGF-A,血小板源性生长因子A抗体

产品编号HZ-10073R
英文名称PDGF-A
中文名称血小板源性生长因子A抗体
别 名Platelet–dirived growth factor–1; PDGFA; PDGF AA; PDGF-AA; PDGF A chain; PDGF subunit A; PDGF-1; PDGF1; PDGFA; PDGFA_HUMAN; Platelet derived growth factor A chain precursor; Platelet derived growth factor alpha polypeptide; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 神经生物学 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit,
PDGF-A,血小板源性生长因子A抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量14kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PDGF-A
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PDGF-A,血小板源性生长因子A抗体PubMedPubMed
产品介绍background:
Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound. Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. The long form contains a basic insert which acts as a cell retention signal. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. It belongs to the PDGF/VEGF growth factor family.

Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.

Subunit:
Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.

Subcellular Location:
Secreted. Note=Released by platelets upon wounding.

PDGF-A,血小板源性生长因子A抗体Tissue Specificity:
Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

Gene ID:
5154

Database links:
Entrez Gene: 5154 Human
Entrez Gene: 5155 Human
Entrez Gene: 18590 Mouse
Entrez Gene: 18591 Mouse
Entrez Gene: 24628 Rat
Entrez Gene: 25266 Rat
Omim: 173430 Human
Omim: 190040 Human
SwissProt: P01127 Human
SwissProt: P04085 Human
SwissProt: P20033 Mouse
SwissProt: P31240 Mouse
SwissProt: P28576 Rat
SwissProt: Q05028 Rat

PDGF-A,血小板源性生长因子A抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PDGF-A（platelet-dirived growth factor-A）是一种碱性蛋白，pdgf促进细胞分裂、增值同时，可诱导c-fos、c-myc等蛋白表达增强。
主要作用：参与组织和血管修复、促进平滑肌细胞、成纤维细胞迅速增值。分子量为28-35kDa，分为两个亚基（A、B链）通过二硫键结合而成的两条多肽链的异二聚体。最新研究发现了PDGF家族两种新的基因PDGF-C、PDGF-D。