吉林省科瑞斯生物科技有限公司
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聚乙丙交酯（PLGA），又名聚乳酸-羟基乙酸共聚物、聚乳酸-乙醇酸共聚物。由两种单体乳酸 和羟基乙酸无规聚合而成，是一种可降解的功能高分子有机化合物，具有良好的生物相容性、无毒、良好 的成囊和成膜的性能，被广泛应用于制药、医用工程材料和现代化工业领域。在美国 PLGA 通过 FDA 认证， 被正式作为药用辅料收录进美国药典。 聚乙丙交酯是无规共聚，无定型聚合物，其玻璃化温度在 40-60℃之间。广泛用于手术缝合线，防粘连膜， 组织工程支架，与 PLA 相比，根据 GA 含量不同可控制聚合物降解时间，材料柔软有弹性。不同的单体比例 可以制备出不同类型的 PLGA，例如：PLGA 75：25 表示该聚合物由 75%乳酸和 25%羟基乙酸组成。PLGA 降解程度随单体比不同而有差异，乙交酯比例越大越易降解。 PLGA 的降解产物是乳酸和羟基乙酸，所以当它应用在医药和生物材料中时不会有毒副作用。通过调整单体 比，进而改变 PLGA 的降解时间，这种方法已广泛应用于生物医学领域中，可用作医用手术防粘连膜，皮 肤移植、伤口缝合、注射用微胶囊、体内植入，微球及埋植剂等缓释制剂的辅料，同时可用作组织工程细胞 培养的多孔支架，孔隙率、孔径和降解速率可调。
Instructions: The alternate name of poly(L-lactide-co-glycolide) (PLGA), is polylactic acid-glycollic acid copolymer. PLGA is produced from lactic acid and glycolic acid. It is non-toxic and has excellent biodegradability, biocompatibility, film or capsule forming ability. PLGA is widely used in pharmaceutical, medical engineering materials and modern industrial fields. In the United States, PLGA has been approved by the FDA and is formally included in the United States pharmacopoeia as pharmaceutical materials. PLGA is a amorphous polymer. The glass transition temperature (Tg) of PLGA is 40 - 60 °C. It has been widely used in medical surgical sutures, anti-adhesion membrane, tissue engineering scaffolds and so on. The degradation rate of PLGA increases with the increase of GA proportion. Different types of PLGA can be produced using different monomer ratio . For example, PLGA 75:25 indicates that the polymer consists of 75% lactic acid and 25% glycolic acid. The degradation products of PLGA are lactic acid and glycolic acid, so they do not have toxic side effects when used as the pharmaceutical and biological materials. PLGA has been widely used in biomedical fields, such as medical anti-adhesion membrane, skin graft, stitched wound, injectable microcapsules, microspheres, implants,scaffolds for tissue engineering.