CISD2抗体
Applications
| In-house applications |
ELISA, WB, IHC, IF, IP, FC Application not tested? Please see our Guarantee. |
| Published applications |
IHC, WB |
Publications |
3 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Drosophila, human, mouse, rat |
|
Images
Prev12Next
 mouse kidney tissue were subjected to SDS PAGE followed by western blot with 13318-1-AP(CISD2 antibody) at dilution of 1:1000 Immunohistochemical of paraffin-embedded human kidney using 13318-1-AP(CISD2 antibody) at dilution of 1:100 (under 40x lens) IP Result of anti-CISD2 (IP:13318-1-AP, 3ug; Detection:13318-1-AP 1:700) with mouse brain tissue lysate 4000ug. Immunofluorescent analysis of HepG2 cells using 13318-1-AP( CISD2 Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IgG 1X10^6 HepG2 cells were stained with 0.2ug CISD2 antibody (13318-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
|
| Positive WB detected in |
Mouse kidney tissue, HeLa cells, human brain tissue, mouse brain tissue, mouse heart tissue |
| Positive IP detected in |
Mouse brain tissue |
| Positive IHC detected in |
Human kidney tissue, human brain tissue, human lung tissue, human ovary tissue, human pancreas tissue, human spleen tissue, human testis tissue |
| Positive IF detected in |
HepG2 cells |
| Positive FC detected in |
HepG2 cells |
| Recommended dilution |
WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200 |
CISD2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
CISD2 fusion protein ag4172 |
Full name |
CDGSH iron sulfur domain 2 |
Calculated molecular
weight |
135aa,15 kDa |
Observed molecular
weight |
13-15 kDa |
GenBank accession
number |
BC032300 |
Gene ID (NCBI) |
493856 |
| Gene symbol |
CISD2 |
Synonyms |
CDGSH iron sulfur domain 2, CDGSH2, CISD2, ERIS, Miner1, MitoNEET related 1 protein, NAF 1, WFS2, ZCD2 |
Background CISD2抗体
|
CISD2 gene encodes a 15 kDa CDGSH iron-sulfur domain-containing protein 2, which is also named Miner1 or NAF-1, this protein was reported on endoplasmic reticulum membrane or mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2), a rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. CISD2 regulates autophagy program by interacting BCL2, contributing to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. CISD2抗体
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