小RNA是生物体内一类具有重要调控功能的非编码小RNA的总称。大量研究已经证实，小RNA几乎参与调控了动植物几乎所有的生命过程，包括细胞增殖，分化，凋亡等，并且与人类疾病的发生发展密切相关。小RNA测序正是对这一类重要的调控小RNA展开分析，利用高通量测序技术对样本中18~30 nt的小RNA序列进行鉴定和分析。依托联川生物强大的生物信息分析平台，可以快速鉴定物种已知小RNA，并预测新的小RNA，同时可对小RNA的靶基因进行预测和功能分析。

一次测序即可获取500万条以上序列。  

 提供Q30以上数据，确保数据分析的准确性。

数据分析采用联川生物开发的数据软件ACGT101-miR，可靠性已经过数百个实验项目检验。

文库构建不再千篇一律，根据实验样本的特点，采用适合的建库方案，获取最全的小RNA数据库。

Nature子刊：揭示Hippo信号新机制 
PLoS One：猪完整发育阶段microRNAome图谱发布
J Gen Virol：利用 miRNA高通量测序技术筛查蚊子携带的RNA病毒 
PLoS ONE：鹌鹑PIWI基因的克隆及其结合小RNA特征的鉴定 
J Virol：miR-181调控猪繁殖与呼吸综合症病毒复制 
中国农大：玉米对于氮营养缺陷应答中相关miRNAs的克隆与鉴定 
四川农大：肌间脂肪组织microRNA调控代谢 

1. Meyer C, Grey F, Kreklywich CN, Andoh TF, Tirabassi RS, Orloff SL, Streblow DN. (2010) Cytomegalovirus MicroRNA Expression Is Tissue Specific and Is Associated with Persistence. J Virol 85(1), 378-89.
2. Li B, Qin Y, Duan H, Yin W, Xia X. (2011) Genome-wide characterization of new and drought stress responsive microRNAs in Populus euphratica. J Exp Bot 62(11), 3765-79.
3. Bortoluzzi S, Bisognin A, Biasolo M, Guglielmelli P, Biamonte F, Norfo R, Manfredini R, Vannucchi AM. (2012) Characterisation and discovery of novel miRNAs and moRNAs in JAK2V617F mutated SET2 cells. Blood 119(13), e120-e130.
4. Guo XK, Zhang Q, Gao L, Li N, Chen XX, Feng WH. (2012) Additional expression of microRNA-181 inhibits Porcine Reproductive and Respiratory Syndrome Virus replication and its implications for controlling virus infection. J Virol .
5. Jayachandran B, Hussain M, Asgari S. (2012) RNA interference as a cellular defense mechanism against the DNA virus, baculovirus. J Virol .
6. Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL. (2012) YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol.
7. Ma M, Huang Y, Gong Z, Zhuang L, Li C, et al. (2011) Discovery of DNA Viruses in Wild-Caught Mosquitoes Using Small RNA High throughput Sequencing. PLoS ONE 6(9), e24758.
8. Fu Y, Shi Z, Wu M, Zhang J, Jia L & Chen X (2011) Identification and differential expression of microRNAs during metamorphosis of the Japanese flounder (Paralichthys olivaceus). PLoS One 6, e22957.
9. Choi J, Kang S, Lee Y, Hong S, Sanek NA, Young WS, Lee H. (2013) MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA. Journal of Neurochemistry
10. Lian L, Qu L, Chen Y, Lamont SJ, Yang N (2012) A Systematic Analysis of miRNA Transcriptome in Marek’s Disease Virus-Induced Lymphoma Reveals Novel and Differentially Expressed miRNAs. PLoS ONE 7(11), e51003.  

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