产品发布日期：PeproTech 2012年9月
Recombinant Murine TPO
 
Catalog Number:
AF-315-14
Synonyms:
Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
Description:
TPO(促血小板生成素)是一种系别特异性的生长因子，在肝、肾和骨骼肌中产生。它刺激巨核细胞的增殖和成熟，并促进体内循环血小板水平的增加。TPO通过c-mpl受体传递信号，并是循环血小板的一个重要调节剂。人和小鼠的TPO具有物种交叉反应活性。重组小鼠TPO是具有完全生物活性的多肽，由174个氨基酸组成(分子量为18.7 kDa)，包含全长TPO蛋白的促红细胞生成素样结构域。生产过程中的所有试剂均为非动物源性。
AA Sequence:
SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
 
Cross Reactivity:
Human
Research Interests:
Cell Culture
Proliferation
Stem Cells & Differentiation
Wound Healing
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.