人脑血管周细胞说明

货号：1200

  
        周细胞是具伸缩性的类似平滑肌细胞的一类细胞，它们覆盖在微脉管的基底面。周细胞是小静脉的主要成分，并普遍存在于毛细血管中。在不同的组织和器官中，周细胞的数量和功能呈现很大的差异。周细胞的三种主要功能是（1）参与中枢神经系统微血管收缩性，（2）内皮细胞活性及（3）巨噬细胞活性的调节。也有证据表明周细胞与血脑屏障的物质转运及血管渗透性的调节有关。病理学研究显示，周细胞与高血压、糖尿病视网膜病变、阿尔海默氏病、多发性硬化和中枢神经系统肿瘤的形成有关。
    人脑血管周细胞 (HBVP)提取于人脑组织，原代冻存。每管含有细胞数 >5×105 cells/ml，此细胞通过对alpha-SMA抗体荧光免疫方法验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
 
推荐培养基：（PM, Cat. No. 1201)
 Discription
        Pericytes are contractile smooth muscle-like cells that cover the abluminal surface of microvessels. They are the most abundant in venules and are common in capillaries. The pericytes population is highly variable between different tissues and organs and appears to show functional heterogeneity [1]. Three major functional roles have been ascribed to pericytes associated with central nervous system microvescular-contractility, regulation of endothelial cell activity, and macrophage activity [2]. There is also evidence that pericytes are involved in the transport across the blood-brain barrier and the regulation of vascular permeability. An important role for pericytes in pathology has been indicated in hypertension, diabetic retinopathy, Alzheimers disease, multiple sclerosis and CNS tumor formation [3].
        HBVP from ScienCell Research Laboratories are isolated from human brain tissue. HBVP are cryopreserved at primary culture and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HBVP are characterized by immunofluorescent method with antibodies to alpha-smooth muscle actin. HBVP are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HBVP are guaranteed to further expand for 15 population doublings in the conditions specified by ScienCell Research Laboratories.

Reference
[1] Sims, D. E. (2000) Diversity within pericytes. Clin. Exp. Pharmacol. Physiol. 27:842-846
[2] Rucker, H. K., Wynder, H. J. and Thomas, W. E. (2000) Cellular mechanisms of CNS pericytes. Brain Res. Bull. 15:363-369.
[3] Allt, G. and Lawrenson, J. G. (2001) Pericytes: cell biology and pathology. Cells Tissues Organs. 169:1-11.

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