Human Growth Factors & Cytokines
Recombinant Human IL-1Ra





 





		Synonyms :
IL-1Ra, ICIL-1RA, IRAP, IL-1RN



		Description :
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein.  It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors.  IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.  Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.  Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.



		Catalog #:
200-01RA



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by its ability to inhibit the IL-1alpha stimulation of murine D10S cell.  The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE 



		PubMed Link :
IL-1Ra


Country of Origin :
USA
















        Size A
20μg
$80 
 


 



        Size B
100μg
$195 
 


 



        Size C
1mg
$1100 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.