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上海复蒙基因生物科技有限公司是美国Sciencell公司中国一级代理：
美国ScienCell研究实验室（www.sciencellonline.com）成立于1999年，公司总部位于美国加州的圣地亚哥。主要致力于实验室科研用原代细胞、原代细胞专用培养基、原代细胞无血清培养基、干细胞、干细胞培养基、干细胞无血清培养基的研究和开发，在全球拥有众多客户。在国内销售8年来，很多老师应用其产品发表了高质量的SCI文章，且有着极高的文献引用率。凭借着严格的质控和优秀的产品品质，深受广大科研工作者的信赖。
ScienCell研究实验室生产的原代细胞、原代细胞专用培养基都经过了严格的质量控制，细胞纯度可达98％。其中包括21种人体正常细胞系统，90多种不同细胞类型。大多数细胞在全球唯有ScienCell实验室能够成功分离，产品质量过硬。确保了实验结果的重复性和连贯性。
请登录Sciencell公司官方网站（www.sciencell-sh.com或www.sciencellonline.com）以确保购买正规公司产品。
 
人气管平滑肌细胞说明：
货号：3410
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气道平滑肌是维持气道张力的根本。它存在于气管、支气管树直至终末支气管。其特异的超微结构特点和调节机制是实现气管正常生理功能的基础。有证据表明气管平滑肌在肺的发育过程以及诸如哮*病、慢性支气管炎和肺气肿等疾病状态下经历着显著的表型变化。另外，气道平滑肌通过分泌细胞因子和趋化因子等促炎介质，发挥免疫调节功能。培养的气管平滑肌细胞能表达三种P21活化的激酶（PAK）的同型异构体和PAK1，并通过P38 mapk信号途径参与气管平滑肌细胞的迁移。气道平滑肌细胞增殖已成为人们关注的焦点，因为在哮*病人中，此细胞是气道壁重塑反应中数量上的重要组分，并被认为是新型抗哮*病药物的作用目标。
人气管平滑肌细胞 (HTSMC)提取于人气管组织，原代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过对alpha-SMA和Desmin免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
推荐培养基:(SMCM, Cat. No. 1101)
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Description
Airway smooth muscle is an important tissue in maintaining airway tone. They exist in the trachea and in the bronchial tree up to the terminal bronchioles. Their specialized ultrastructural features and regulatory mechanisms are the basis of normal airway function. Evidence suggests that airway smooth muscle undergoes marked phenotypic modulation in lung development and in disease states such as asthma, chronic bronchitis and emphysema. Airway smooth muscle may also serve immunomodulatory functions, which are mediated by the secretion of pro-inflammatory mediators such as cytokines and chemokines [1]. Cultured tracheal smooth muscle cells express three p21-activated kinase (PAK) isoforms and PAK1 participates in tracheal smooth muscle cell migration by signaling to p38 Mapk [2]. Airway smooth muscle cell proliferation has been the focus of considerable attention, as it is a quantitatively important component of the airway wall remodeling response in asthma and has been suggested as a suitable target for the development of novel anti-asthma agents.
HTSMC from ScienCell Research Laboratories are isolated from human trachea. HTSMC are cryopreserved at secondary culture and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HTSMC are characterized by immunofluorescent method with antibodies to ?-smooth muscle actin and desmin. HTSMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HTSMC are guaranteed to further expand for 15 population doublings at the condition provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Smooth Muscle Cell Medium (SMCM, Cat. No. 1101) for the culturing of HTSMC in vitro.
Product Use
HTSMC are for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures.
Storage
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Shipping
Dry ice.
Reference
[1] Amrani Y, Panettieri RA. (2003) Airway smooth muscle: contraction and beyond. Int J Biochem Cell Biol. 35(3):272-6.
[2] Dechert MA, Holder JM, Gerthoffer WT. (2001) p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 Mapk. Am J Physiol Cell Physiol. 281(1):C123-32.
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7.肺部细胞系统
3000 人肺微血管内皮细胞 (HPMEC)( 5×105 )
3100 人肺动脉内皮细胞(HPAEC) ( 5×105 )
3110 人肺动脉平滑肌细胞(HPASMC) ( 5×105 )
3120 人肺动脉成纤维细胞 (HPAF)( 5×105 )
3200 人肺泡上皮细胞 (HPAEpiC)( 1×106 )
3210 人支气管上皮细胞（HBEpiC）（5×105 )
3220 人气管上皮细胞（HTEpiC）（5×105 )
3230 人小气管上皮细胞（HSAEpiC）（5×105 )
3300 人肺成纤维细胞 (HPF)( 5×105 )
3400 人支气管平滑肌细胞 (HBSMC)( 5×105 )
3410 人气管平滑肌细胞 (HTSMC)( 5×105 )
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复蒙基因|FMGBio(www.fmgbio.com/ www.sciencell-sh.com/ )成立于2005年， 是专业从事牛血清生产、销售高端的原代细胞类科研产品。这些产品从根本上提高了全球生命医学研究、人类重要疾病药物研发、新药研发的成功率。近几年的新药研发成功率在逐年下降，其根本原因之一就是传统的药物筛选系统是建立在只具有30-40%人类基因群的一系列细胞株上。这样一个有“缺陷型”药物筛选系统所产生的药物用于人体上就会出现许多致命的弱点和不完整性。新一代药物筛选系统是含有一系列近乎完整的人类基因群的原代细胞株。而利用这些原代细胞株所甄别和筛选出来的候选药物，其诊治人类疾病的成功几率将大大增加。这样不但大大节省了新药的开发成本，而且将极大地提高人类的健康质量。
复蒙基因|FMGBio现有的产品：美国Sciencell（原代细胞、原代细胞专用培养基、无血清培养基）、3D Bioteck（三维细胞培养支架）、年产1000万毫升的内蒙古牛血清生产基地等。
复蒙基因|FMGBio的PI团队已经发展到专职PI 20人，联席PI 312人，其中大多数拥有海外背景。截止到2009年3月，以PI或联席PI为第一作者发表SCI 论文1682 篇（总IF 值为5721.82，其中影响因子IF>5.0 的论文216 篇，IF>10.0论文32 篇）。
电话：021-51262076 13371892488 13816636051
Email:wwwfudan@163.com QQ：739782475 QQ:2451036669
网址：www.fmgbio.com/ www.sciencell-sh.com/
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