Recombinant Rat FGF-acidic
Catalog Number:
400-29A
Synonyms:
Fibroblast Growth Factor-acidic, FGF-1, HBGF-1, ECGF-beta
Description:
FGF-acidic is one of 23 known members of the FGF family.  Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.  FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells.  FGF-acidic has the ability to signal through all the FGF receptors.  Recombinant rat FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.
AA Sequence:
MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
Source:
E.coli
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by a cell proliferation assay using balb/c 3T3 cells.  The expected ED50 is ≤ 0.1 ng/ml, in the presence of 10 µg/ml heparin, corresponding to a specific activity of ≥ 1 x 107 units/mg.
 
 
 
 
Research Interests:


    

        

            

            
Angiogenesis/ Cardiovascular
            

            
Cancer
        
        

            

            
Cell Culture
            

            
FGF Superfamily
        
        

            

            
Neurobiology
            

            
Proliferation
        
        

            

            
Stem Cells & Differentiation
            

            
Wound Healing
        
    


 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.