Recombinant Rat GM-CSF
 
Catalog Number:
AF-400-23
Synonyms:
Granulocyte/Macrophage, Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-α
Description:
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells.  It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes.  GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells.  The human and murine molecules are species-specific and exhibit no cross-species reactivity.  Recombinant murine GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues. Manufactured using all non-animal reagents.
AA Sequence:
MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The expected ED50 is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 108 units/mg.
 
 
 
 
Research Interests:
Cancer
Cell Culture
Inflammation
Proliferation
Stem Cells & Differentiation
Wound Healing
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.