LIS1/RARA FISH Probe
产品名称： LIS1/RARA FISH Probe
英文名称： LIS1/RARA FISH Probe
产品编号： FA0650
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Supplied Product:
- DAPI Counterstain (150 ng/mL) 250 uL
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Entrez GeneID:
- 5048
- Gene Name:
- PAFAH1B1
- Gene Alias:
- LIS1,LIS2,MDCR,MDS,PAFAH
- Gene Description:
- platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq
- Other Designations:
- Platelet-activating factor acetylhydrolase, isoform 1B, alpha subunit,lissencephaly 1 protein,platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit
- Entrez GeneID:
- 5914
- Gene Name:
- RARA
- Gene Alias:
- NR1B1,RAR
- Gene Description:
- retinoic acid receptor, alpha
- Omim ID:
- 180240
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM
- Other Designations:
- OTTHUMP00000164454,OTTHUMP00000164456,Retinoic acid receptor, alpha polypeptide,nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form