Recombinant Murine IL-9

Catalog Number:

219-19

Synonyms:

p40 cytokine, T-cell growth factor p40

Description:

IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkins disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant murine IL-9 is a 14.3 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins.

AA Sequence:

MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED₅₀ as determined by the dose-dependent proliferation of human MO7e cells is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 10⁶units/mg.

Cross Reactivity:

Human, Mouse

Research Interests:

Cancer

Proliferation

Country of Origin:

USA

Research Use Only. Not for use in diagnostic or therapeutic procedures.