Recombinant Human PTGDS, His-tagged
产品名称: Recombinant Human PTGDS, His-tagged
英文名称: Recombinant Human PTGDS, His-tagged
产品编号: PTGDS-8578H
产品价格: 0
产品产地: USA
品牌商标: Creative Biomart
更新时间: null
使用范围: null
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PTGDS, also known as L-PGDS, is a member of the calycin superfamily, lipocalin family. It is abundantly expressed in the heart, brain, and central nervous system(CNS), where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter.