Biotinylated Human VEGF165, epitope tag free, ultra sensitivity (primary amine labeling)北京百普赛斯生物科技有限公司

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产品名称: Biotinylated Human VEGF165, epitope tag free, ultra sensitivity (primary amine labeling)
英文名称: Biotinylated Human VEGF165, epitope tag free, ultra sensitivity (primary amine labeling)
产品货号: VE5-H8210
产品规格: 200ug
试剂级别: 试剂级
产品产地: USA
产品商标: ACROBiosystems
价    格: 13800元
保存与运输: 保存:-20℃运输:粉末,常温
现货状态: 现货
产品资料: 实验方法技术资料
更新时间: 2017-3-21 17:07:00
浏览人数:792
诚信指数:435点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京百普赛斯生物科技有限公司
地址:
北京经济技术开发区地盛中路3号B座109
邮编:
100176
电话:
400-682-2521
传真:
+86 10-6580-0635
联系人:
张女士
所在区域:
北京·北京
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公司展台:
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产品详细描述

分子量:19 kDa (monomer)

纯度:>95% as determined by reduced SDS-PAGE. 

内毒素:Less than 1.0 EU per μg by the LAL method.

Buffer:PBS, pH7.4

生物活性:(1) Measured by its binding ability in a functional ELISA against immobilized VEGFR2/R3-Fc (0.5 g/well).The linear range is 0.5-5 ng/mL.
(2) Measured by its binding ability in a functional ELISA against immobilized Human Neuropilin-1, His Tag (Cat # NR1-H5228, 0.2 μg/well). The linear range is 5-40 ng/mL.

产品特性:The product does NOT contain any epitope tags. The protein has a calculated MW of 19 kDa (monomer). The protein migrates as 24 kDa (monomer) on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 43-50 kDa under non-reducing (NR) condition.

产品背景:VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2  that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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