分子量:49.5 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human FAM3B, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:

产品特性:Human FAM3B, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 49.5 kDa. The predicted N-terminus is Glu 30. The reducing (R) protein migrates as 50-65 kDa in SDS-PAGE  due to glycosylation.

产品背景:Protein FAM3B,a cytokine-like protein identified in 2002,is also known as cytokine-like protein 2-21, pancreatic-derived factor (PANDER), C21orf11 and C21orf76,which is highly expressed in the pancreas and also found in the colon, kidney, prostate, small intestine and testis. There are 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.