内毒素:

Less than 1.0 EU per μg by the LAL method.



纯度:

>95% as determined by SDS-PAGE.



活性:

Measured by its binding ability in a functional ELISA. Immobilized Human LAG-3, Fc Tag (Catalog # LA3-H5255) at 2μg/mL (100 μL/well) can bind Anti-LAG3 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL.



产品背景:

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.



产品描述:

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.3 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
SDS-PAGE


Human LAG3, Fc Tag on SDS-PAGE  under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.