Human CTLA-4 / CD152 Protein, low endotoxin北京百普赛斯生物科技有限公司

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产品名称: Human CTLA-4 / CD152 Protein, low endotoxin
英文名称: Human CTLA-4 / CD152 Protein, low endotoxin
产品货号: CT4-H522a
产品规格: 1mg
产品产地: USA
产品商标: ACROBiosystems
价    格: 14000元
现货状态: 大量
产品资料: 实验方法技术资料
更新时间: 2018/6/18 10:55:00
浏览人数:1
诚信指数:589点
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使用范围:仅限科研使用,不能应用于临床
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北京百普赛斯生物科技有限公司
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北京经济技术开发区宏达北路8号5号楼4层
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100176
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400-682-2521
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所在区域:
北京·北京
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产品详细描述

内毒素:
Less than 0.01 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Immobilized Human B7-2, Fc Tag (Cat. No. CD6-H5257) at 2μg/mL (100 μL/well) can bind Human CTLA-4, His Tag, low endotoxin (Cat. No. CT4-H522a) with a linear range of 1-6.4 ng/mL (Routinely tested).

产品背景:
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

产品描述:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.4 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to different extent glycosylation.
因为难以在供应系统上进行数据同步,所以了解更多产品规格及产品数据,请移步:
http://www.acrobiosystems.cn/P1299-Human_CTLA-4_%7C_CD152_Protein_low_endotoxin.html 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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