Human PD-1 / PDCD1 Protein (HPLC-verified), low endotoxin北京百普赛斯生物科技有限公司

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产品名称: Human PD-1 / PDCD1 Protein (HPLC-verified), low endotoxin
英文名称: Human PD-1 / PDCD1 Protein (HPLC-verified), low endotoxin
产品货号: PD1-H522a
产品规格: 1mg
产品产地: USA
产品商标: ACROBiosystems
价    格: 24000元
现货状态: 大量
产品资料: 实验方法技术资料
更新时间: 2018/8/13 12:09:00
浏览人数:2
诚信指数:597点
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使用范围:仅限科研使用,不能应用于临床
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北京百普赛斯生物科技有限公司
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产品详细描述

内毒素:
Less than 0.01 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Immobilized Human PD-1, His Tag, low endotoxin (Cat. No. PD1-H522a) at 0.2μg/mL (100 μL/well) can bind Human PD-L1, Fc Tag (Cat. No. PD1-H5258) with a linear range of 0.31-1.25 μg/mL (QC tested).

产品背景:
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.

产品描述:
This protein carries a polyhistidine tag at the C-terminus, and has a calculated MW of 16.8 kDa. The N-terminus Sequence Analysis is Leu 25. The reducing (R) protein migrates as 31-44 kDa in SDS-PAGE  due to glycosylation.
因为难以在供应系统上进行数据同步,所以了解更多产品规格及产品数据,请移步:
http://www.acrobiosystems.cn/P1303-Human_PD-1_%7C_PDCD1_Protein_HPLC-verified_low_endotoxin.html 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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