Blood vessels of the skin are composed of a number of cellular and non-cellular elements. The predominant cell type in all skin blood vessels is the endothelial cell. Endothelial cells form the interface between intravascular and extravascular compartments and serve as a selective barrier for the diffusion of cells and macromolecules between these two compartments. The endothelial cells lining blood vessels of the skin share features of endothelial cells elsewhere in the body, but they also exhibit several skin specific characteristics. They are active participants in a variety of physiological processes. These include wound healing, control of hemostasis, temperature regulation, and the modulation of inflammation/leukocyte trafficking [1, 2]. The structure and function of endothelial cells are differentially regulated in space and time . Endothelial cell proliferation, quiescence, apoptosis, and senescence are the four principal cytologic states that set the cutaneous microvascular in a dynamic balance between maintenance and remodeling .
It is recommended to use Endothelial Cell Medium (ECM, Cat. No. 1001) for the culturing of HDMEC-a.
HDMEC-a are for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures.
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments
 Swerlick, R. A and Lawley, T. J. (1993) Role of microvascular endothelial cells in inflammation. J. Invest. Dermatol. 100:111S.
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