E-64
产品名称： E-64
英文名称： E-64 Protease inhibitor
产品编号： H00042
产品价格： 0
产品产地： 中国，Alabiochem
品牌商标： Alabiochem
更新时间： null
使用范围： null
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- 所在区域 : 江苏
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| Products： | L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide |
| Products No.： | H00042 |
| Synonyms: | E-64 |
| Cas No.： | 66701-25-5 |
| Molecular Formula： | C15H27N5O5 |
| Molecular Weight： | 357.41 |
| Pruity Limit： | 98.5% |
| Assay Limit： | 99% |
| Appearance： | White powder |
| Storage Temp： | -5℃~-20℃ |
Background:
A new class of compounds that show promise of acting as class-specific inhibitors for the cysteine proteinases are the L-trans-epoxysuccinylpeptides related to the compound E-64 [L-trans-epoxysuccinyl-L-leucylamido(4-guanidino)butanel , isolated from cultures of Aspergillus. E-64 was shown to inhibit papain, ficin and the fruit and stem bromelains, with disappearance of the thiol group of papain1.
References:
1. A. J. BARRETT, A. A. KEMBHAVI, L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. (1982) 201, 189-198
2. Towatari, T., Tanaka, K., Yoshikawa, D. & Katunuma, N. (1978).J. Biochem. (Tokyo) 84, 659-671.
3. Mort, J. S., Recklies, A. D. & Poole, A. R. (1980) Biochim. Biophys. Acta 614, 134-143.
4. Hanada, K., Tamai, M., Morimoto, S., Adachi, T.,Ohmura, S., Sawada, J. & Tanaka, I. (1978a) Agric. Biol. Chem. 42, 537-541.
5. Hanada, K., Tamai, M., Ohmura, S., Sawada, J., Seki, T.& Tanaka, I. (1978b)Agric. Biol. Chem. 42, 529-536