IL-22, Human
产品名称: IL-22, Human
英文名称:
产品编号: CB055-1891
产品价格: 0
产品产地: 美国
品牌商标: ExCell Bio
更新时间: null
使用范围: null
上海吉泰依科赛生物科技有限公司
- 联系人 :
- 地址 : 上海市徐汇区桂平路481号18号楼5层
- 邮编 : 200233
- 所在区域 : 上海
- 电话 : 021-6439-8855
- 传真 : (86 21)33676258
- 邮箱 : marketing@excellbio.com
Interleukin-22(IL-22) belongs to a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20℃, IL-24, and IL-26) which are a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, such as IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens in epithelial cells such as those in the lung and gut. IL-22 along with IL-17 is produced by splenic LTi-like cells and Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.IL-22 signals through a receptor system consisting of IL-10R-/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
Recombinant human Interleukin-22 (IL-22) produced in E. coli is a single non-glycosylated polypeptide chain containing 147 amino acids. A fully biologically active molecule, rhIL-22 has a molecular mass of 16.9 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at ExCell Bio.