英文名称：Human Uterine Fibroblasts
During pregnancy, in order to accommodate the growing embryo the uterus undergoes
widespread remodeling and dramatic extracellular matrix changes . Studies suggest that
activated human uterine fibroblasts (HUF) organize and direct the extracellular matrix
remodeling in the uterus throughout pregnancy . Fibroblasts are mesenchymal cells derived
from the embryonic mesoderm. They have been extensively used for a wide range of cellular and
molecular studies as they are one of easiest types of cells to grow in culture. Uterine fibroblasts
secrete a non-rigid extracellular matrix which is rich in type I and/or type III collagen [2, 3].
Cultured Human Uterine Fibroblasts (HUF) are a useful in vitro model to study pregnancy and
female reproductive disorders.
HUF from ScienCell Research Laboratories are isolated from human uterus. HUF are
cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105
cells in 1 ml
volume. HUF are characterized by immunofluorescence with antibody specific to fibronectin.
HUF are negative for mycoplasma, bacteria, yeast, and fungi. HUF are guaranteed to further
expand for 15 population doublings under the conditions provided by ScienCell Research
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