产品名称：大鼠星形胶质细胞-成年

货号：R1860
 

Astrocytes are the most abundant cell type in the central nervous system (CNS) and they provide a variety of vital functions for the CNS including: establishment and regulation of the blood brain barrier, functional support for neuronal transmission, survival of neurons, anti-inflammatory responses and wound repair [1]. Astrocytes have also been implicated in various pathological processes such as reactive gliosis [2]. Impairment of normal astrocyte functions during stroke and other insults can critically influence neuron survival. Long-term recovery after brain injury, through neurite outgrowth, synaptic plasticity, or neuron regeneration, is also influenced by astrocyte surface molecule expression and trophic factor release [3]. Numerous studies have demonstrated that astrocytes are among the most functionally diverse group of cells in the CNS [4]. Rat astrocytes-adult (RA-a) are a useful in vitro model for studying adult glial function and the molecular mechanisms of CNS diseases such as ischemic stroke and multiple sclerosis.

RA-a from ScienCell Research Laboratories are isolated from adult rat brain. RA-a are cryopreserved after purification and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. RA-a are characterized by immunofluorescence with antibody specific to GFAP. RA-a are negative for mycoplasma, bacteria, yeast, and fungi. RA-a are guaranteed to further expand for 5 population doublings under the conditions provided by ScienCell Research Laboratories. 

Recommended Medium

It is recommended to use Astrocyte Medium-animal (AM-a, Cat. #1831) for culturing RA-a in vitro.