分子量:10.2 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human S100A6, Tag Free by the LAL method.

Buffer:PBS, pH7.4

生物活性:The bio-activity of S100A6 was determined by its binding ability with human CEACAM3 protein in the presence of 100 mM CaCl2.

产品特性:Human S100A6, Tag Free contains no "tag", and has a calculated MW of 10.2 kDa. The predicted N-terminus is Met 1 . The reducing (R) protein migrates as 10.2 kDa in SDS-PAGE .

产品背景:S100 calcium binding protein A6 (S100-A6) is also kown as 2A9, 5B10, CABP, CACY and PRA, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100A6 may function in stimulation of Ca2+ -dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. S100A6 has been shown to interact with S100B and SUGT1.