Recombinant Human HPRG
Catalog Number:
100-60
Synonyms:
Histidine-Proline-Rich Glycoprotein, Histidine-rich glycoprotein (HRG), HRGP, THPH11
Description:
Histidine-proline-rich glycoprotein (HPRG), a member of the Cystatin structural superfamily, is an abundantly secreted multi-domain glycoprotein. Although the physiological function is largely unknown, HPRG potentially regulates physiological processes such as cell adhesion and migration, fibrinolysis, coagulation, complement activation, immune complex clearance and phagocytosis of apoptotic cells. HPRG can exert anti-angiogneic activity by stimulating apoptosis of endothelial cells. Recombinant Human HPRG is a 57.7 kDa glycoprotein containing 507 amino acid residues.
AA Sequence:
VSPTDCSAVE PEAEKALDLI NKRRRDGYLF QLLRIADAHL DRVENTTVYY LVLDVQESDC SVLSRKYWND CEPPDSRRPS EIVIGQCKVI ATRHSHESQD LRVIDFNCTT SSVSSALANT KDSPVLIDFF EDTERYRKQA NKALEKYKEE NDDFASFRVD RIERVARVRG GEGTGYFVDF SVRNCPRHHF PRHPNVFGFC RADLFYDVEA LDLESPKNLV INCEVFDPQE HENINGVPPH LGHPFHWGGH ERSSTTKPPF KPHGSRDHHH PHKPHEHGPP PPPDERDHSH GPPLPQGPPP LLPMSCSSCQ HATFGTNGAQ RHSHNNNSSD LHPHKHHSHE QHPHGHHPHA HHPHEHDTHR QHPHGHHPHG HHPHGHHPHG HHPHGHHPHC HDFQDYGPCD PPPHNQGHCC HGHGPPPGHL RRRGPGKGPR PFHCRQIGSV YRLPPLRKGE VLPLPEANFP SFPLPHHKHP LKPDNQPFPQ SVSESCPGKF KSGFPQVSMF FTHTFPK
Source:
CHO cells
Purity:
Greater than 90% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Measured by its ability to support adhesion of Con-A activated MOLT-4 cells to the Recombinant Human HPRG-coated surface. The ED50 for this effect is 1.5-2.0 μg/ml.
 
 
 
 
Research Interests:


    

        

            

            
Angiogenesis/ Cardiovascular
            

            
Apoptosis
        
        

            

            
Cancer
            

            
Chemotaxis
        
        

            

            
Immune System
            

            
Proliferation
        
    


 
 
Country of Origin:
USA