重组人TIM-3蛋白-蛋白质/抗原/多肽-试剂-生物在线
重组人TIM-3蛋白

重组人TIM-3蛋白

商家询价

产品名称: 重组人TIM-3蛋白

英文名称: Recombinant Human TIM-3 protein

产品编号: GMP-TL731

产品价格:

产品产地: China

品牌商标: 同立海源生物

更新时间: 2023-08-22T16:21:23

使用范围: null

规格 价格
100μg 3000.0
北京同立海源生物科技有限公司
  • 联系人 : 崔女士
  • 地址 : 北京市大兴区中关村科技园区大兴生物医药产业基地华佗路50号院13号楼
  • 邮编 : 100085
  • 所在区域 : 北京
  • 电话 : 186****3653
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  • 邮箱 : cuilimei@seafrom.cn

重组人TIM-3蛋白(Recombinant Human TIM-3 protein),GMP级

 

产品货号:GMP-TL731


 

产品描述(Description)

 

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

 

 

 

分子别名(Synonym)

 

HAVCR2、TIM3、TIMD3、FLJ14428、KIM3

 

 

 

表达宿主(Expression host)

 

HEK293 细胞

 

 

 

来源(Source)

 

Human

 

 

 

蛋白序列(Protein Sequence)

 

DNA 序列编码人 TIM3( NCBI Reference Sequence:NP_116171.3)表达带有 Fc 标签在 C 末端

 

 

 

分子量(Molecular Weight)

 

重组人 TIM-3 蛋白包含 412 个氨基酸,预测理论分子量为 49.5 kD

 

 

 

纯度(Purity)

 

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

 

 

 

内毒素(Endotoxin)

 

<0.1EU/ug

 

 

 

生物活性 (Biological Activity)

 

固定人 TIM-3(Fc 标签)1ug/mL (100uL/孔) 能够结合抗人 TIM-3 的抗体的线性范围是 0.1-5ng/mL

 

 

 

组成(Component)

 

含有6%甘露醇的无菌PBS(PH 7.4)的冻干粉

 

 

 

稳定性(Stability)

 

冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融

 

 


参考文献


1、 Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines Feifei Pu, Fengxia Chen, Zhicai Zhang, Jing Feng, Ping Xia Future Sci OA. 2018 Jun; 4(5): FSO298. Published online 2018 Mar 15. doi: 10.4155/fsoa-2017-0121 

2、 Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung CancerChih-Hsi Scott Kuo, Chien-Ying Liu, Stelios Pavlidis, Yu-Lun Lo, Yen-Wen Wang, Chih-Hung Chen, How-Wen Ko, Fu-Tsai Chung, Tin-Yu Lin, Tsai-Yu Wang, Kang-Yun Lee, Yi-Ke Guo, Tzu-Hao Wang, Cheng-Ta Yang Front Immunol. 2018; 9: 232. Published online 2018 Feb 12. doi: 10.3389/fimmu.2018.00232


 


  注意:For research and manufacturing use.