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B-Raf(V600E)

1. Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma
Mod Pathol. 2013 Mar;26(3):414-20.

2. Immunohistochemistry as a quick screening method for clinical detection of BRAF(V600E) mutation in melanoma patients
Tumor Biology. June 2014, Volume 35, Issue 6, pp 5727-5733

3. Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma
human pathology. February 2015Volume 46, Issue 2, Pages 169–175

4. BRAF V600E Mutation-Specific Antibody: A Review
Seminars in Diagnostic Pathology

5. A novel approach for the detection and genetic analysis of live melanoma circulating tumor cells
PLoS One. 2015 Mar 25;10(3):e0123376. doi: 10.1371

6. Utility of BRAF V600E immunohistochemistry expression pattern as a surrogate of BRAF mutation status in 154 patients with advanced melanoma
Human Pathology. Available online 6 May 2015

7. Concomitant High Expression of BRAFV600E, P-cadherin and cadherin 6 is Associated with High TNM Stage and Lymph Node Metastasis in Conventional Papillary Thyroid Carcinoma
Clin Endocrinol (Oxf). 2015 Aug 18. doi: 10.1111

8. Activation of Grm1 expression by inducible mutated B-RAF in vitro and in vivo
2015

9. Immunohistochemistry as a Reliable Method for Detection of BRAF-V600E Mutation in Melanoma: A Systematic Review and Meta-Analysis of Current Published Literature
Journal of Surgical Research. Available online 23 April 2016

10. BRAFV600E and NRASQ61L/Q61R mutation analysis in metastatic melanoma using immunohistochemistry: a study of 754 cases highlighting potential pitfalls and guidelines for interpretation and reporting.
Histopathology. 2016 May 6. doi: 10.1111

B-Raf mAb

1. Comparison of 2 monoclonal antibodies for immunohistochemical detection of BRAF V600E mutation in malignant melanoma, pulmonary carcinoma, gastrointestinal carcinoma, thyroid carcinoma, and gliomas
human pathology. November 2013Volume 44, Issue 11, Pages 2563–2570

EGFR(L858R)

1. Immunohistochemistry with a novel mutation-specific monoclonal antibody as a screening tool for the EGFR L858R mutational status in primary lung adenocarcinoma
Tumor Biology. October 2014

IDH(R132H)

1. Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas
Brain Tumor Pathology. January 2015, Volume 32, Issue 1, pp 3-11

IDH2(R172K) & IDH2(R140Q)

1. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
Nature 513, 110–114 (04 September 2014)

2. Metabolomic comparison between cells overexpressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism
Journal of Neurochemistry. Volume 132, Issue 2, pages 183–193, January 2015

Ras mutation

1. Are all RAS mutations the same? Coexisting KRAS and NRAS mutations in a caecal adenocarcinoma and contiguous tubulovillous adenoma.
J Clin Pathol. 2015 Apr 29. pii: jclinpath-2015-202969. doi: 10.1136

2. DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model
Gene Therapy 21, 888-896 (October 2014)

3. Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model
Citation: Molecular Therapy Nucleic Acids (2016) 5, e282; doi:10.1038

CAMP

1. Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1
Pflugers Arch. 2012 Feb;463(2):257-68

2. Antiarrhythmic effect of prolonged morphine exposure is accompanied by altered myocardial adenylyl cyclase signaling in rats
Pharmacol Rep. 2012;64(2):351-9

3. Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid beta(1-42)
Neuropharmacology. 2013 Apr;67:272-83

4. Subendocardial Increase in Reactive Oxygen Species Production Affects Regional Contractile Function in Ischemic Heart Failure
Antioxid Redox Signal. 2013 Mar 20;18(9):1009-20

5. Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1
Pflugers Arch. 2012 Feb;463(2):257-68

6. Structural basis of anthrax edema factor neutralization by a neutralizing antibody
Biochemical and Biophysical Research Communications Volume 417, Issue 1, 6 January 2012, Pages 324–329

7. Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats
Pflügers Archiv - European Journal of Physiology October 2013, Volume 465, Issue 10, pp 1477-1486

8. Opposing HDAC4 nuclear fluxes due to phosphorylation by β adrenergic activated PKA or by activity or Epac activated CaMKII in skeletal muscle fibres
The Journal of Physiology Volume 591, Issue 14, pages 3605–3623, July 2013

9. Sex is a major determinant of neuronal dysfunction in Neurofibromatosis Type 1
Annals of Neurology Volume 75, Issue 2, pages 309–316, February 2014

10. cAMP–PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3–Orai1 complex
Pflügers Archiv - European Journal of Physiology October 2014, Volume 466, Issue 10, pp 1921-1932

CAMP

11. Immunomodulating effects of casein-derived peptide QEPVL and QEPV on lymphocytes in vitro and in vivo
Food Funct., 2014,5, 2061-2069

12. Agonist-Dependent And -Independent Dopamine-1-Like Receptor Signalling Differently Regulates Downstream Effectors
FEBS Journal Volume 281, Issue 21, pages 4792–4804, November 2014

13. Alteration of vascular reactivity in heart failure: Role of phosphodiesterases type 3 and 4
British Journal of Pharmacology Volume 171, Issue 23, pages 5361–5375, December 2014

14. Ischemia/Reperfusion-Induced CHOP Expression Promotes Apoptosis and Impairs Renal Function Recovery: The Role of Acidosis and GPR4
PLoS One. 2014 Oct 24;9(10):e110944

15. Comparative study of somatostatin-human serum albumin fusion proteins and natural somatostatin on receptor binding, internalization and activation
PLoS One. 2014 Feb 27;9(2):e89932

16. Caffeine Ameliorates High Energy Diet-Induced Hepatic Steatosis: Sirtuin 3 Acts as a Bridge in Lipid Metabolism Pathway
Food & Function. Food Funct., 2015, Accepted Manuscript. DOI: 10.1039/C5FO00247H. 2015

17. Comparative Effects of Urocortins and Stresscopin on Cardiac Myocyte Contractility
J Mol Cell Cardiol. 2015 Jul 28. pii: S0022-2828(15)30026-2. doi: 10.1016

18. Positive effect of carbon sources on natural transformation in Escherichia coli: the role of low-level cAMP-CRP in the derepression of rpoS.
J Bacteriol. 2015 Aug 10. pii: JB.00291-15.

19. Deletion of HAPS_2096 Increases Sensitivity to Cecropin B in Haemophilus parasuis
J Mol Microbiol Biotechnol. 2015 Aug 21;25(4):284-291

20. The effects of IGF1 on the melanogenesis in alpaca melanocytes in vitro.
In Vitro Cell Dev Biol Anim. 2016 May 12.

CGMP

1. Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates the relaxation of porcine pulmonary arteries to nitric oxide
Pflugers Arch. 2013 Feb;465(2):333-41

2. Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation
Circ Res. 2012 Jan 20;110(2):295-303

3. Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17681-6

4. Role of sulfhydryl-dependent dimerization of soluble guanylyl cyclase in relaxation of porcine coronary artery to nitric oxide
Cardiovasc Res. 2011 Jun 1;90(3):565-72

5. Molt-inhibiting hormone from Chinese mitten crab (Eriocheir sinensis): Cloning, tissue expression and effects of recombinant peptide on ecdysteroid secretion of YOs
Gen Comp Endocrinol. 2011 Sep 15;173(3):467-74

6. Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism
PLoS One. 2011;6(11):e27187

7. Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish
Comp Biochem Physiol B Biochem Mol Biol. 2011 Jan;158(1):46-55

8. Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes
Circ Res. 2010 Nov 12;107(10):1232-40

9. The Soluble Guanylate Cyclase Activator BAY 58-2667 Protects against Morbidity and Mortality in Endotoxic Shock by Recoupling Organ Systems
PLoS One. 2013 Aug 28;8(8):e72155

10. Stimulation of guanylyl cyclase-D by bicarbonate
Biochemistry. 2009 May 26;48(20):4417-22

11. Volume overload induces differential spatiotemporal regulation of myocardial soluble guanylyl cyclase in eccentric hypertrophy and heart failure
Journal of Molecular and Cellular Cardiology Volume 60, July 2013, Pages 72–83

12. Defining Specificity Determinants of Cyclic GMP-Mediated Gustatory Sensory Transduction in Caenorhabditis elegans
genetics.113.152660v1 194/4/885

13. The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice
Redox Biology Volume 1, Issue 1, 2013, Pages 498–507

14. Cross regulation between cGMP-dependent protein kinase and Akt in vasodilatation of porcine pulmonary artery
Journal of Cardiovascular Pharmacology: November 2014 - Volume 64 - Issue 5 - p 452-459

15. Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting
Hepatology Volume 60, Issue 6, pages 1929–1941, December 2014

16. The vasodilatory effect of sulfur dioxide via sGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization.
Am J Physiol Regul Integr Comp Physiol. 2016 Mar 23:ajpregu.00101.2015. doi: 10.1152

17. Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium.
J Control Release. 2016 Sep 22. pii: S0168-3659(16)30801-X. doi: 10.1016

Arf6

1. The cytohesin guanosine exchange factors (GEFs) are required to promote HGF‐mediated renal recovery after acute kidney injury (AKI) in mice
Physiological Reports Published 26 June 2015 Vol. 3 no. e12442

Cdc42

1. Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling
PLoS Pathog. 2013 Jan;9(1):e1003142

2. Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells
Cytokine. 2012 Jan;57(1):158-68

Cdc42

3. Invadopodia and rolling-type motility are specific features of highly invasive p190bcr-abl leukemic cells
European Journal of Cell Biology Volume 91, Issues 11–12, November–December 2012, Pages 978–987

4. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
J Cell Biol. 2012 Aug 20;198(4):677-93

5. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42
Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L32-42

6. The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor beta-Stimulated Aortic Endothelial Cells
Mol Cell Biol. 2011 Nov;31(22):4430-41

7. MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex
PLoS One. 2013 Jul 19;8(7):e70123

8. p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
PLoS One. 2013 Sep 3;8(9):e73063

9. The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts
J Biol Chem. 2014 Jun 27;289(26):18347-59

10. The α4 Nicotinic Receptor Promotes CD4+ T-Cell Proliferation and a Helper T-Cell Immune Response
Molecular Pharmacology January 2014 vol. 85 no. 1 50-61

11. Actin Remodeling by Nck Regulates Endothelial Lumen Formation
Mol Biol Cell. 2015 Jul 8. pii: mbc.E15-06-0338.

12. Mutations of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene Cause a Monocyte-selective Adhesion Deficiency
Am J Respir Crit Care Med. 2015 Dec 22.

13. Thiopurine prodrugs mediate immunosuppressive effects by interfering with Rac1 function
Journal of Biological Chemistry (Impact Factor: 4.57). 05/2016; DOI: 10.1074/jbc.M115.694422

14. Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice.
Eur J Immunol. 2016 May 17. doi: 10.1002

15. Nitric oxide increases the migratory activity of non-small cell lung cancer cells via AKT-mediated integrin αv and β1 upregulation
Cell Oncol (Dordr). 2016 Jul 4

16. Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter
Mol Cell Biochem. 2016 Nov 10

17. Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling
Apoptosis. 2016 Nov 18

Gα13

1. Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization
J Biol Chem. 2011 Sep 2;286(35):31055-61

2. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Galpha and beta-arrestin-2
Br J Pharmacol. 2011 Feb;162(3):733-48

3. Gα12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation
Carcinogenesis (2010)

4. Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency
J Biol Chem. 2009 Oct 2;284(40):27409-15

5. B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency
J Immunol. 2015 Jul 31. pii: 1500523.

Gαi

1. Identification of novel signalling roles and targets for Galpha and Gbetagamma downstream of the insulin-like growth factor 1 receptor in vascular smooth muscle cells
Biochem J. 2013 Feb 15;450(1):209-19

2. CRH activation of different signaling pathways results in differential calcium signaling in human pregnant myometrium before and during labor
J Clin Endocrinol Metab. 2012 Oct;97(10):E1851-61

3. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma
Cancer Res. 2012 Jan 1;72(1):122-32

4. Regulation of estradiol and progesterone production by CRH-R1 and -R2 is through divergent signaling pathways in cultured human placental trophoblasts
Endocrinology. 2012 Oct;153(10):4918-28

5. WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins
Cell Signal. 2011 Mar;23(3):550-4

6. Heterotrimeric Galpha(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis
Biochim Biophys Acta. 2011 Mar;1813(3):466-72

7. Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I
Steroids Volume 77, Issue 5, April 2012, Pages 424–432

8. Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits
J Biol Chem. 2010 Aug 27;285(35):26976-86

9. Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):628-32

10. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin
Mol Biol Cell. 2014 Nov 5;25(22):3654-71

11. Canonical and Non-canonical G-protein

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