Sotatercept
MCE 国际站：Sotatercept
CAS：1001080-50-7
品牌：MedChemExpress (MCE)
存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性：Sotatercept (ACE-011) 是一种可溶性激活素受体 2A (ACVR2A) 型 IgG Fc 融合蛋白。Sotatercept 结合了激活素和生长分化因子，试图恢复生长促进和生长抑制信号通路之间的平衡。Sotatercept 在肺动脉高压、贫血、骨质流失、红细胞生成、多发性骨髓瘤 (MM) 溶骨性病变中有潜在的应用。
体外：Sotatercept (100 μg/mL) 下调了基质细胞分泌的 VEGF、抑瘤素 M (OSM)、IL-6、BMP-2、MMP-1 和 MMP13 表达水平[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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研究领域：TGF-beta/Smad
作用靶点：TGF-β Receptor
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参考文献：
[1]. Humbert M, et al. Sotatercept for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2021 Apr 1;384(13):1204-1215. [2]. Raje N, et al. Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss. Curr Opin Mol Ther. 2010 Oct;12(5):586-97.[3]. Abdulkadyrov KM, et al. Sotatercept in patients with osteolytic lesions of multiple myeloma. Br J Haematol. 2014 Jun;165(6):814-23.[4]. Sherman ML, et al. Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women. J Clin Pharmacol. 2013 Nov;53(11):1121-30. [5]. Iancu-Rubin C, et al. Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap. Exp Hematol. 2013 Feb;41(2):155-166.e17.