5'-Methylthioadenosine
MCE 国际站:5'-Methylthioadenosine
CAS:2457-80-9
品牌:MedChemExpress (MCE)
存储条件:-20°C, protect from light
生物活性:5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) 是多胺合成过程中由 S-腺苷甲硫氨酸 (SAM) 生成的核苷[1]。 5'-Methylthioadenosine 通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡来抑制肿瘤,同时控制肿瘤组织的炎症微环境。 5'-甲硫腺苷及其相关物质对肿瘤发生具有显着的调控作用[2]。 体外:5'-甲基硫腺苷对 MTAP+ 细胞的保护作用明显优于 MTAP ? 细胞来自 6TG(6'-硫鸟嘌呤)毒性[3]。 体内:2FA(2'-氟腺嘌呤)+ MTA(5'-甲硫腺苷)组合(100 mg/kg MTA;20 mg/kg 2FA)抑制肿瘤生长小鼠异种移植模型中的四种不同 MTAP? 人类肿瘤细胞系[3]。
体外:5'-甲硫腺苷对 MTAP+ 细胞的保护作用明显优于 MTAP− 细胞免受 6TG(6'-硫鸟嘌呤)的影响毒性[3]。
体内:2FA(2'-氟腺嘌呤)+ MTA(5'-甲硫腺苷)组合(100 mg/kg MTA;20 mg/kg 2FA)抑制四种不同MTAP−</ sup> 小鼠异种移植模型中的人肿瘤细胞系[3].
热销产品:Tirzepatide | Hoechst 33342 | Acetaminophen | Spermidine | ISRIB (trans-isomer) | Iptacopan (hydrochloride) | 6-Diazo-5-oxo-L-nor-Leucine | NAI-N3 | PNU-159682 | Abatacept
研究领域:Metabolic Enzyme/Protease | Apoptosis | Anti-infection
作用靶点:Endogenous Metabolite | Apoptosis | Parasite
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸
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参考文献:
[1]. Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.[2]. Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.[3]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.[4]. Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.