Thiolutin | 硫藤黄素
MCE 国际站:Thiolutin
中文名:硫藤黄素
CAS:87-11-6
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性: Thiolutin (Acetopyrrothin) 是一种含二硫化物的抗生素和抗血管生成化合物,由 Streptomyces 产生。硫卢丁抑制 JAMM 金属蛋白酶 Csn5、SH3 STAM 结构域相关分子 (AMSH) 和 Brcc36[1]。 Thiolutin 是一种有效的选择性内皮细胞粘附抑制剂,可快速诱导热休克蛋白 beta-1 (Hsp27) 磷酸化[2]。
热销产品:Sulforaphane | Infliximab | Nicotinamide | Carboplatin | AP20187 | Vancomycin (hydrochloride) | Urelumab | CCCP | Calcitriol | Simvastatin
研究领域:Anti-infection | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage
作用靶点:Bacterial | Antibiotic | Endogenous Metabolite | Deubiquitinase
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:
[1]. Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.[2]. Jia Y, et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones. 2010 Mar;15(2):165-81.