Estrone sulfate (sodium)
MCE 国际站:Estrone sulfate (sodium)
CAS:438-67-5
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:硫酸雌酮是雌激素的一种无生物活性形式,是一种主要的循环血浆雌激素,可通过类固醇硫酸酯酶 (STS) 转化为具有生物活性的雌激素雌酮 (E1)。硫酸酮可用于乳腺癌的研究[1][2]。 体外 T47D 细胞用 SOAT 稳定转染,并在生理相关浓度的不断增加的硫酸雌酮和雌二醇浓度下孵育。 1 nM 雌二醇和硫酸雌酮显着增加细胞增殖,EC50 为 2.2 nM[3]。
体外:T47D 细胞用 SOAT 稳定转染,并在生理相关浓度的不断增加的硫酸雌酮和雌二醇浓度下孵育。 1 nM 雌二醇和硫酸雌酮显着增加细胞增殖,EC50 为 2.2 nM[3]。
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研究领域:Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease
作用靶点:Estrogen Receptor/ERR | Endogenous Metabolite
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸
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参考文献:
[1]. Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339. [2]. Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303.[3]. Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21.